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Its common adverse reactions are similar to other GLP-1 drugs, primarily consisting of gastrointestinal issues (nausea, diarrhea, vomiting, etc.), which are mostly mild to moderate and typically decrease over time
An experimental model of GLP-1R knockout mice (GLP-1R-/-) [37] demonstrated that (GLP-1R-/-) mice exhibited only modest decreases in gonadal weight, while females exhibited delayed puberty, but subsequent fertility and sex-steroid secretion were normal
JCI Insight 6 , e143245 (2021)
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