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Clinical trials have demonstrated its safety and tolerability as an effective treatment for obesity

They are indicated for type 2 diabetes management, weight reduction in obesity, and cardiovascular risk reduction, with ongoing investigation into metabolic dysfunction-associated steatohepatitis, chronic kidney disease, and heart failure with preserved ejection fraction

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Many patients with type 2 diabetes have coexisting cardiovascular conditions that necessitate beta blocker therapy, and clinical experience supports the safety of using these medications together under appropriate medical supervision