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In the STEP 1 trial which studied semaglutide in adults with overweight or obesity, researchers studied body mass composition as a secondary endpoint via DXA in a subpopulation of trial enrollees randomized to treatment or placebo
From food, peptides, to thoughts
Bech EM, Martos-Maldonado MC, Wismann P, et al
This difference was achieved without any change in food intake, suggesting the weight loss came from metabolic changes rather than appetite suppression
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