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Sustained activation of the PERK-eIF2-ATF4 pathway has been strongly associated with EMT induction, survival under chemotherapeutic stress, and metastatic competence

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To avoid ascertainment bias due to differences in duration of medication use in the two comparison groups, we created a new propensity score-matched cohort including the duration of follow-up based on per-protocol analysis, using the same previous specifications of the primary analysis