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This stability partially explains why both nasal and oral administration routes remain viable options for delivery
Hypoxia and inflammation activate p53 via phosphorylation
It has been studied for decades in skin biology and is widely used as an active ingredient in topical skincare
Its mechanism of action centers on upregulation of growth factor expression, particularly vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF), which accelerate angiogenesis and tissue granulation 5
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