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It suppresses the IL-6/STAT3 pathway, thereby preventing the HCC cells from inhibiting the cytotoxic effect mediated by natural killer cells (NKs) ( + T cells and induce immunity to tumor rechallenge in Hepa16 allograft mice ( pos CD3 + T cells treated with exendin-4 secreted less IFN-, exhibited weaker migration ability, and upregulated genes related to apoptosis, immunoregulation, and immune deficiency, such as CASP3 and CASP7

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Its essential to note that these positive changes resulted from a combination of Graves disease medication and the comprehensive program we implemented, as Caroline was solely dependent on medication at the beginning of the year

doi: 10.1038/ijo.2013.120 46 VallisMBoylandECaroliMErhardtEFrelutMLMazurAet al