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In the ATTAIN-MAINTAIN trial, 205 patients taking tirzepatide and 171 patients taking semaglutide were randomized to take orforglipron or placebo (no active drug) daily for a year

I also experienced suicidal thoughts and ideations toward the end of my treatment, but I didn't want my derm to pull me off the medsat that point in my life, I thought my skin was more important than my mental health, but I should have been upfront with my dermatologist ( I absolutely dont recommend this dangerous behavior, FYI )

doi:10.1097/MOG.0b013e3280b17dfb

SGLT2 inhibitors exert multiple effects, including activating autophagy and suppressing pyroptosis and ferroptosis, to mitigate tubular injury and kidney damage (119, 156, 205, 206)

Wu, J., Wang, C., Sun, J