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Hepatol Int
A: NAC (N-acetyl cysteine) 600mg daily, $1218/month
A 2025 JACC Case Reports case documented an interaction consistent with this model: tirzepatide producing a 27 bpm supine heart rate increase in a POTS patient approximately nine times the mean reported in non-POTS populations attributed by the authors to compromised autonomic regulation of cardiac output distribution (Hedge et al., 2025)
doi:10.1016/j.emospa.2009.08.001
Ann Pharmacother (2020) 54(5):47885
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