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Retatrutide is the lead candidate in this category, but is still in clinical trials
The best evidence for weight loss comes from a meta-analysis of 37 trials: a modest average reduction of about 1.2 kg (under 3 lbs), mostly in adults who are overweight
Oral semaglutide 25mg achieved average weight loss of 16.6% at 64 weeks, while orforglipron 36mg achieved 12.4% at 72 weeks
These anti-tumor effects exhibit considerable heterogeneity across various tumor types
It is the first time any obesity medication has reached 30%+ average weight loss in a Phase 3 trial
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