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Consistent with the pharmacological results, the above results provide convincing evidence that the GPX4 overexpression protects TECs from ferroptosis and mitigates renal interstitial fibrosis

These data suggest a potential for long-term benefit of liraglutide treatment in many patients, as weight loss of 515% has been shown to improve obesity-related complications including diabetes and cardiovascular disease risk factors [5, 9, 59]

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This is exactly why these medications should be used as part of a comprehensive program that includes nutrition education, behavioral support, and a long-term maintenance strategy