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Participants were randomized to placebo or one of five retatrutide dose groups (1 mg, 4 mg escalating, 4 mg fixed, 8 mg escalating, 12 mg escalating)
10.1038/nature10209 56 KhorutsA.DicksvedJ.JanssonJ
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In 537 patients with type 2 diabetes (85% treatment-naive), the trial showed HbA1c reductions up to 2.0% and weight loss up to 16.8% at 40 weeks, with no plateau
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