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Physical examination should assess for signs of chronic liver disease, though these are often absent in early MASLD

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Although results may not be instant, improvements can be observed within a relatively short period

NNMT is expressed at high levels in the liver and is also present in adipose tissue, kidney, brain, lung, heart, and skeletal muscle

Most available data consists of observational reports from weight loss clinics where multiple interventions (caloric restriction, exercise programs, behavioral counseling) are implemented simultaneously, making it impossible to isolate the contribution of lipotropic injections