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When symptoms occur, they typically relate to underlying conditions such as liver disease, kidney dysfunction, or haematological disorders that cause the elevation, rather than the high B12 itself

And long-term safety studies in humans would address the most significant remaining uncertainty about the compound

What they found: Favorable safety profile , no serious adverse events at doses up to 100 g/kg Preliminary efficacy signals positive The program stopped before Phase 3 for unknown commercial reasons (the program passed through several sponsor rotations and no one ultimately carried it through) Why it matters: These are the only published clinical data in humans that we have

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