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Annu Rev Biophys
What forms the bulk of the retail price2 of peptides is not the cost of manufacturing, but the capital infrastructure: the regulatory burden, the cold chain logistics, the pen device (which sometimes costs more than the drug itself), and, above all, the return needed to justify $9 billion in the initial R&D of these GLP-1 drugs
A helpful framework comes from insulin titration
"A History of Paracetamol, Its Various Uses & How It Affects You"
The clinical evidence base established for FDA-approved finished drug products does not automatically apply to compounded preparations
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