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SCFAs stimulate GLP-1 secretion from intestinal L cells via free fatty acid receptors (FFAR2/3), enhancing endogenous GLP-1 release in a nutrient-dependent manner ( This contrast between signal intensity and biological context has important implications

It is also a key player in the function and development of brain and nerve cells

Diabetes 60:15351543 Tian G, Tepikin AV, Tengholm A, Gylfe E (2012) cAMP induces stromal interaction molecule 1 (STIM1) puncta but neither Orai1 protein clustering nor store-operated Ca 2+ entry (SOCE) in islet cells

Dieting increases the likelihood of subsequent obesity and BMI gain: Results from a prospective study of an Australian national sample

Overall, results confirmed a positive effect of pre- and probiotics for weight support