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It works by increasing the concentration of neurotransmitters that naturally suppress pain signaling in the spinal cord

Those observations inspire laboratory experiments

J Cell Mol Med 29(17):e70799 Sobstyl M, Niedwiedzka-Rystwej P, Grywalska E, Korona-Gowniak I, Sobstyl A, Bednarek W et al (2020) Toll-like receptor 2 expression as a new hallmark of advanced endometriosis

They must be in good overall health and do not have any mental or physical condition that requires frequent medication

[26, 27] Model outputs include life expectancy (measured in years), quality-adjusted life expectancy (measured in quality-adjusted life years [QALYs]), cumulative incidence of all modeled T2D-related complications and costs