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NICE recommends Wegovy as part of specialist weight management services with regular monitoring, typically limiting treatment to a maximum of 2 years
However, the Glu 138 -Phe 143 sequence clearly has -helical propensity, which is in agreement with the recent crystal structure of the homologous glucagon receptor TM domain showing an extracellular -helical extension of TM1 20
Receptor binding affinity (EC 50 , Human) = 5
It enhances glucose-dependent insulin secretion, keeping blood sugar stable without the hypoglycemic crashes that drive cravings
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