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Studies suggest that TREK-1 blockade increases serotonin release in the dorsal raphe nucleus and hippocampus, mimicking the downstream effects of SSRI antidepressants but through an ion channel mechanism rather than reuptake inhibition

Theres even an upcoming phase 2 trial that will study whether GLP-1s affect depressive symptoms in people with major depressive disorder

Unlike many drugs, GLP-1 receptor agonists are broken down by enzymes throughout the body rather than through liver metabolism

They are usually dose-related and often settle with slower dose escalation and smaller meals. Cosmetic dermatologists are seeing patients daily who have lost weight after taking semaglutide A 2025 study found that for every 1,000 people taking semaglutide, fewer than four had to be rushed to the emergency room, most often for serious gastrointestinal problems

Tax-Efficient Transitions of Appreciated Securities Proper tax management is especially important when exiting securities with appreciated gains