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Only 11.2% of participants stopped the trial due to side effects, and the discontinuation rate dropped significantly after week 24, suggesting those who make it through the early phase generally tolerate it well long-term

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3.2 Evidence from Observational and Intervention Studies Few studies have examined the relationship between metformin use and skeletal muscle health such studies are challenging because metformin is currently indicated for use in T2DM a condition which is itself implicated in accelerated ageing and muscle dysfunction