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Potential Adverse Effects The FDA flagged concerns about: Immunogenicity and antibody formation with repeated dosing Peptide-related impurities from compounding pharmacy manufacturing Unknown effects on cardiovascular, hepatic, and renal function with chronic use Theoretical acceleration of undetected tumor growth Current Research Gaps The literature reveals critical knowledge deficits preventing definitive cancer risk conclusions: Long-term human safety: No prospective study has followed BPC-157 users for months or years to document cancer incidence or tumor progression

first published 2020, updated 2024.

Studies using Campbell rats with hereditary retinal degeneration confirmed these findings, showing Epithalon treatment maintained rod photoreceptor structure and prevented progressive retinal cell death