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Elastin, which the body largely stops producing after puberty, gradually fragments and loses its recoil properties

Dyslipidaemia (odds ratio (OR) 1.6), hypertension (OR 1.5), and concurrent biologic therapy (OR 1.5) were all associated with increased likelihood of GLP-1 agonist use, highlighting the interconnected nature of metabolic and inflammatory conditions in HS management

Additionally, the GIPR variant rs1800437 (p.Glu354Gln) is already a known partial loss-of-function mutation, previously identified in a study of Chinese type 2 diabetes patients in 2019

H., Lee, J

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