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Apr 2014;16(2):141-150
Altogether, these findings indicate that the antioxidant effects of metformin are achieved by Nrf2 nuclear translocation, increased downstream cytoplasmic HO-1 expression, and the subsequent activation of Nrf2 dependent signaling pathway
Ahn and Brown, 2005 Ilniczky etal, 2003: Beltramello etal, 1998: Rosener and DIchgans, 1996), neurotoxicity (Johnsonn etal, 2018), neuronopathy (Morris etal, 2015), polyneuropathy (Alarcia etal, 1999), psychosis (Sethi etal, 2006), dementia (El Otmani etal, 2007), ataxia (Miller etal, 2004), megaloblastic anemia (Barbosa etal, 2000), neurological impairment (McNeeely etal, 2000), neurologic decompensation (Felmet etal, 2000), neurologic degeneration (Flippo and Holder, 1993), spastic paraparesis (Lee etal, 1999)
Once you open a vial and draw a dose, you should not use it again because contamination can occur
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