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In the Phase IV study, semaglutide will be evaluated for its effects on improving depressive symptoms over 26 weeks in patients with major depressive disorder who also have overweight or obesity (Vinberg, 2026, ID NCT07136714)
For example, our NMN + Trans-Resveratrol formula supports NAD+ levels, which are also vital for cellular energy and are depleted by alcohol
You should contact your GP or mental health team urgently if you experience any of the following whilst taking Mounjaro: Significant changes in mood (either elevated or depressed) Increased anxiety or agitation Changes in sleep patterns (insomnia or excessive sleeping) Thoughts of self-harm or suicide (if at immediate risk, call 999 or go to A&E) Severe or persistent gastrointestinal symptoms affecting your ability to eat or take medications Signs of dehydration Symptoms of hypoglycaemia if also taking insulin or sulfonylureas (shakiness, sweating, confusion) Additionally, seek medical advice if you notice any unusual physical symptoms such as: Severe abdominal pain Persistent vomiting Signs of pancreatitis (severe upper abdominal pain radiating to the back) Symptoms of gallbladder disease (pain in the right upper abdomen, fever, jaundice) Symptoms of thyroid problems (lump in the neck, hoarseness, difficulty swallowing) Changes in vision, particularly if you have diabetic retinopathy While rare, these require prompt medical assessment
Uncropped images of key gels are presented in Supplementary Fig
Gold PW, Goodwin FK, Chrousos GP
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