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The company finally decided to pull Vioxx from shelves in 2004, after additional studies revealed an increased risk of strokes and heart attacks among patients taking the drug for 18 months or longer

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[Updated Aug 18, 2021]

The absence of a documented direct mechanism does not entirely exclude the possibility of skin changes occurring during treatment, but it suggests that any such effects are likely uncommon and may result from indirect factors rather than a direct pharmacological action of semaglutide on sebaceous glands or skin physiology

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