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[1] [2] In clinical practice, prednisolone may be used to treat: Severe allergic rhinitis that has not responded adequately to antihistamines or intranasal corticosteroids as a short, exceptional course under GP or specialist supervision Acute histaminergic urticaria (hives) and histaminergic angioedema where antihistamines alone have not provided sufficient relief Severe asthma exacerbations triggered by allergens oral prednisolone 4050 mg daily for at least five days is recommended for adults in UK guidelines (BTS/SIGN) [9] [10] Severe flares of atopic eczema or allergic contact dermatitis reserved for cases where topical treatments have failed, under GP or specialist guidance, given the risk of rebound on withdrawal It is important to note that adrenaline (epinephrine) is the first-line emergency treatment for anaphylaxis , as recommended by the Resuscitation Council UK (2021) and NICE NG183
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The approval came after a five-year SELECT trial funded by Wegovys manufacturer, Novo Nordisk, found that a weekly dose of 2.4 milligrams (mg) of semaglutide may be effective at lowering the risk of morbidity from heart disease and stroke in people who are overweight or with obesity but do not have diabetes
More information can be found under 'Periodic safety update reports: questions and answers'
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