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Chemical structures of lipoic acid and lipoyllysine residue The figure illustrates the chemical structures of lipoic acid in its oxidized and reduced forms, its two enantiomers ( R - and S -lipoic acid), and its covalent attachment to a lysine residue of the E2 component of the -ketoacid dehydrogenase complex (and the H protein of the glycine cleavage system), forming a lipoyllysine moiety

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Surveillance data from 2014 to 2024 demonstrated a sustained upward trajectory in NAE reports associated with GLP-1 RAs, peaking in 20232024 (Fig

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33 The reabsorption of glucose from the tubule is accomplished by sodium-glucose cotransporters (SGLTs)