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[Oleaceae] and the fruits of Ligustrum lucidum W.T.Aiton [Oleaceae], induces Nrf2 nuclear translocation, enhancing antioxidant defenses in ethanol-challenged hepatocytes (Liu et al., 2014)
Phase 3 trials, which involve larger and more diverse populations over longer durations, are currently underway (see ClinicalTrials.gov for registered studies) and will provide more robust evidence before any regulatory submission can be considered
Data analysis was predetermined and performed blind to expected outcomes
Dati tossicologici preclinici: Studi di tossicit acuta e subacuta nei ratti non hanno rivelato mortalit o tossicit significativa a livello degli organi, anche a dosi ben superiori a quelle terapeutiche (fino a 100 volte la dose efficace)
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