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Renal GLP-1 resistance, associated with attenuated natriuretic responses to GLP-1 has been observed in subjects with T2D (40, 41)

Peripheral lipolysis increases through GIP receptor effects on adipocytes, mobilizing stored fat for oxidation

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that flexibility, curiosity, and attunement to each unique situation and personal circumstances are necessary for quality care. Why Psychological Support Matters The World Health Organization, in its updated guidance on GLP-1 medications for obesity, has named Intensive Behavioral Therapy (IBT) as a key component of comprehensive care, not a supplementary option, but a recognized clinical necessity