Sigma-1 receptor is involved in degradation of intranuclear inclusions in a cellular model of Huntingtons disease
Micera et al., 2001
Methods Study Design This was a single-center (United States), randomized, double-blind, placebo-controlled, single-dose, two-way crossover, phase IV study (NCT04155047) conducted between November 7, 2019, and March 31, 2020
In addition, it is important to notice that the ubiquitous DPP-IV protease targets not only GLP-1 but also oxyntomodulin, GIP and PYY among other proteins (235)
The inhibitory action of 1 mmol/l DON was specific to glutamine-triggered GLP-1 release, as it impaired neither basal secretion nor secretion triggered by 10 mmol/l glucose or forskolin plus IBMX (10 mol/l each)