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Tirzepatide also acts centrally to reduce appetite and food intake by affecting areas of the brain involved in appetite regulation
Importantly, the greatest weight loss was typically not seen during the first few weeks but rather after sustained treatment
The study couldnt explain that difference, but Mavromatis noted that differences in blood drug concentration, weight loss, metabolism or hormones could be at play
Disruption of cerebral metabolic homeostasis is thought to be a cornerstone of migraine pathophysiology (19, 21)
What can be said is that the triple-agonist mechanism appears to produce a steeper dose-response curve than either the dual-agonist (tirzepatide) or single-agonist (semaglutide) approach
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