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Semaglutide and endometriosis: the most studied connection As the most widely prescribed GLP-1 agonist, semaglutide has the most patient-reported data for endometriosis-related outcomes

Ellingsgaard H, Seelig E, Timper K et al (2020) GLP-1 secretion is regulated by IL-6 signalling: a randomised, placebo-controlled study

That does not mean oral options can never work, but injections currently offer the best-documented outcomes

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It is a pre-requisite for reimbursement and is separate to the reimbursement arrangements