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Other key interactions include a hydrogen bond between the carbonyl oxygen and Arg125 and a salt bridge between the amino group and residues Glu205 and Glu206 as illustrated in (Figure 2)
Those numbers are significantly better than what semaglutide (Wegovy/Ozempic) achieves on its own
Other drugs are available that can be used to treat diabetes
One possibility is that amyloid precursor protein (APP) binds to GLP-1 as a G-protein-coupled receptor, resulting in reduced APP synthesis
This allows the nutrient to be delivered directly to the cells that need it most
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