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Some patients attempt longer intervals to reduce cost or needle anxiety, but these short-term savings evaporate when you need higher doses later to recapture lost weight loss, or when you stop the medication altogether due to inconsistent results and frustration

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Influence on Pituitary Somatotroph Cells Beyond stimulating acute GH release, repeated GHRHR activation has been associated in preclinical studies with increased somatotroph cell proliferation and enhanced pituitary responsiveness to GHRH

clinically it presents with atrophic depressions or saccular outpouchings of the skin

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