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GLP-1s dont melt your muscle by designthey reduce appetite so aggressively that people under-eat protein and stop lifting
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The Role of Short-Chain Fatty Acids When beneficial bacteria ferment food they produce compounds called short-chain fatty acids
It is well known that HFD-induced obesity promotes low-grade hypothalamic inflammation, causing deregulation of central mechanisms that control energy homeostasis 59 , and both physical exercise and some pharmacotherapies have been shown to improve systemic metabolism by attenuating hypothalamic inflammation 60,61
Both medications were tested in large clinical trials with thousands of people who didnt have diabetes
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