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NICE guidelines for type 2 diabetes (NG28) recommend reviewing GLP-1 treatment at around 6 months and continuing only if there has been a meaningful reduction in HbA1c (typically at least 11 mmol/mol [1%]) and weight loss of at least 3% of initial body weight
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Z.PetrovicI.SucicM.et al (2016)
Why this may happen: Obesity can disrupt hormone balance and interfere with regular ovulation
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