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10.2174/0929867328666210406115529 33 DanhierF.DanhierP.De SaedeleerC
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D.B., L.B., L.G., and A.E
4 How Mounjaro works Mounjaro activates two hormone receptors instead of one: Like Rybelsus, it activates the GLP-1 receptor It also activates GIP (glucose-dependent insulinotropic polypeptide), a second gut hormone involved in appetite regulation and blood sugar control This dual-action mechanism likely explains why tirzepatide produces greater weight loss and improvements in blood sugar in clinical trials than GLP-1-only medications
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