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This increase was maintained following treatment with LPS

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TGF- is a central regulator of fibroblast activity and collagen gene expression

Left ventricular cardiac function was measured in all patients pre-operatively at baseline before the administration of L-carnitine or placebo and 12 h post-operatively using conventional echocardiography to assess left ventricular ejection fraction (LVEF) and two-dimensional speckle tracking echocardiography (2D-STE) to determine left ventricular global longitudinal strain (2D-LV GLS)

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