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iPSC clones and introduction of the doxycycline-inducible NGN2 expression vector We used an iPSC clone obtained from a DS patient and a trisomy-corrected isogenic clone generated from the trisomy clone as previously described 25
These studies suggest that with aging, the presence of the E4 allele may contribute to alterations in the L-carnitine bioenergetic system and to the generation of L-carnitine metabolites that could have detrimental effects on the vascular system
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Switching to Tirosint is an option for many patients because most endocrinologists and PCPs are willing to prescribe T4-only medications over T3 preparations and Tirosint is a T4-only medication
Carnitine deficiencies also are found in patients undergoing hemodialysis or those affected by any one of various organic acidemias/acidurias (e.g
