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No head-to-head Phase 3 data between retatrutide and tirzepatide was available at the time of the TRIUMPH-4 readout

The subsequent downstream signaling cascade initiated from substrates of the insulin receptor activates kinases and transcription factors vital in promoting cell metabolism, neuronal growth and differentiation, gene transcription, synaptic plasticity, and neuroprotection [133] (Fig

Methods: The study sample comprised 993 adults (Females 68%)