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Aside from the molecules mentioned above, several other compounds with anti-ferroptotic properties have demonstrated antifibrotic effects in various organs besides the lungs, and hold promise for potential therapeutic application in PF
Glutathione-S-transferase (GSTP) that participates in the conjugation of GSH to reactive cysteines (S-glutathionylation) seems to play an important role in idiopathic pulmonary fibrosis lung fibrogenesis, since GSTP immunoreactivity is increased in the lungs of idiopathic pulmonary fibrosis patients, notably within type II epithelial cells (128, 129)
J Biol Chem 2004;279:55008-16
& Magnus, T
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