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Direct measurements of carnitine in skeletal muscles failed to show any elevation in the muscle carnitine concentration following 14 days of 4 g/day [21], or 6 g/day [22] LC ingestion

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For instance, Casgevy, based on the CRISPR/Cas9 gene-editing system, was the first successful attempt at disease treatment, promising a one-time treatment for a lifelong effect. However, the complexity of clinical applications and the difficulty of target selection in gene editing have led to long treatment cycles and high costs