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Key findings In an eight-week randomized, double-blind, placebo-controlled trial involving 50 adults seeking treatment for moderate-to-severe AUD, participants receiving oral semaglutide showed: Fewer heavy drinking days Reduced alcohol consumption per drinking occasion Lower day-to-day alcohol cravings Fewer alcohol-related problems Improved overall drinking risk level Reduced cannabis use days While not all measures changed in controlled laboratory settings, the overall pattern showed consistent reductions in harmful real-world drinking behavior
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10.3 Treatment and adjunctive management General principles include addressing comorbid symptoms (such as sleep, mood, memory, fatigue, and psychiatric disorders), emphasizing self-management tools, and employing multimodal therapies that combine several non-pharmacologic strategies
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The pixels of inflamed edematous regions with high signal intensity in the axial image were measured using the Image J 1.52a software (National Institutes of Health, USA), and a comparative analysis between the control group and Si-based agent-treated group was conducted
