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Henricsson M, Nilsson A, Janzon L, Groop L
Nature Medicine, 28 (10), 20822091
supplementation has demonstrated increased maximal oxygen consumption and modest weight loss in meta-analyses of overweight adults
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The FDA provides examples of acceptable documentation for the significant difference determination, including: No Dye X, patient allergy (if the comparable drug contains the dye) Liquid form, patient cant swallow tablet (if the comparable drug is a tablet) 6 mg, patient needs higher dose (if the comparable drug is only available in 5 mg dose) For providers offering weight management services, remember that the prescription documentation needs to establish why combining the GLP-1 with an additive results in a significant difference compared to administering them separately
