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(7) I A Vinogradova 1, A V Bukalev, M A Zabezhinski, A V Semenchenko, V Kh Khavinson, and V N Anisimov (2007) Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes Bulletin of Experimental Biology and Medicine, 2007 Dec, Volume 144 (Issue 6), Pages 825-30

Serious side effects are rare but worth knowing about

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It can be found naturally in the roots & leaves of the comfrey plant, but more often than not what's in the cosmetic products is produced synthetically

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