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Methionine and cysteine residues are vulnerable to oxidation, especially under light or trace metal exposure (Manning et al., Pharm Res, 2010)
Increased body temperature
A systematic review found no clinical safety data beyond a very small case series, emphasizing that the safety profile for chronic use in humans remains uncharacterized
Fas-stimulated generation of reactive oxygen species or exogenous oxidative stress sensitize cells to Fas-mediated apoptosis
Exogenous substances like N-acetylcysteine can raise the intracellular amounts of GSH [110]
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