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The tight negative feedback control that glutathione (GSH) exerts on the first of two enzymes responsible for glutathione synthesis, GCL, can explain this phenomenon
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Arthritis Foundation
Selective induction of ligandin [PMID: 3718531] Laboratory literature summary: Propylthiouracil inducible glutathione transferases
The combination protocol is a logical extension of that literature, with mechanistic complementarity supported by the known biology of both compounds
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