According to the Cleveland Clinic, slowing digestion is part of how GLP-1s workwhich means that small, easy-to-digest meals are often better tolerated
Both Eli Lilly, maker of Zepbound and Mounjaro, and Novo Nordisk have seen success with oral versions of their drugs in recent clinical trials
For retatrutide, Urva et al., 2022 reported in the first-in-human study a terminal half-life of about 5 to 7 days, corresponding to roughly 144 to 165 hours, with a maximum plasma concentration after about 1 to 3 days and dose-proportional kinetics
A non-peptide GLP-1 pill called orforglipron is also showing promising results
In contrast, vitamin B12 supplements are most effective when taken on an empty stomachat least two hours after you eat or 30 minutes before your next meal