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It functions as a cofactor for lysyl oxidase (the enzyme responsible for collagen cross-linking and stabilization), ceruloplasmin (a copper transport protein with antioxidant activity), and superoxide dismutase (SOD, a primary antioxidant defense enzyme)

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There is no known antidote, and supportive management is recommended in the case of overdose ( In this case, the patient had been suffering from depression for years without receiving psychiatric medications or psychotherapy

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Each pathway targets specific aspects of vascular and cellular integrity, contributing to the overall protection and remodeling of the retinal vasculature in conditions like DR and ischemic retinal diseases (see Figure 5)