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PEG-coated gold nanoparticles (PEG-AuNPs) also demonstrate potent antioxidant signaling modulation in diabetic RIRI models by activating the AMPKNrf2 pathway, which increases HO-1, SOD, and GPx expression, lowers MDA levels, improves serum creatinine and BUN, and confers mitochondrial protection at the ultrastructural level [79]

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