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Figure 2 Within the SOC level, gastrointestinal system disorders in overall GLP-1 RAs were overreported compared with the background frequency (ROR 1.46, PRR 1.33, IC 0.41, EBGM 1.33), which were further attributed to liraglutide (ROR 2.39, PRR 1.84, IC 0.88, EBGM 1.33), dulaglutide (ROR 1.39, PRR 1.28, IC 0.36, EBGM 1.25), and semaglutide (ROR 3.00, PRR 2.10, IC 1.07, EBGM 2.10), while exenatide (ROR 0.57, PRR 0.63, IC 0.68, EBGM 0.63) and lixisenatide (ROR 0.51, PRR 0.57, IC 0.81, EBGM 0.57) did not show the association with gastrointestinal AEs ( Table 2 )
However, it did not significantly alter gut microbiome composition or SCFA production, which may require a longer period of nutritional intervention (69)
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